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Nfl Week 5 Odds 2025. The most sizable point spreads when it comes to nfl week 5. After some rather precarious week 4 results, the super bowl odds are on the move.

We’ll be tracking the nfl week 5 odds with the favorite, moneyline, spread, and over/under odds for all 14 games as we have our first bye weeks of the season. Take a look at the odds for every week 5 game, courtesy of betmgm, followed by pff greenline and pff staff best bets.